| Identification | Back Directory | [Name]
Cycloguanil | [CAS]
516-21-2 | [Synonyms]
WR-5473
Chlorazin
Aids007020
Aids-007020
Cycloguanyl
Cycloguanil
Cycloguanil-d6
Cycloguanil HCl
CYCLOCHLOROGUANIDE
609-78-9 (Pamoate)
Chlorguanide triazine
Nsc3074(hydrochloride)
152-53-4 (Hydrochloride)
1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
6,6-Dimethyl-5-(4-chlorophenyl)-5,6-dihydro-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl- | [Molecular Formula]
C11H14ClN5 | [MDL Number]
MFCD00838855 | [MOL File]
516-21-2.mol | [Molecular Weight]
251.72 |
| Chemical Properties | Back Directory | [Melting point ]
146° | [Boiling point ]
397.13°C (rough estimate) | [density ]
1.2332 (rough estimate) | [refractive index ]
1.6110 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Antimalarial. | [Definition]
ChEBI: Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent, an antiparasitic agent, an antimalarial, an antiprotozoal drug and an antifolate. |
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