| Identification | Back Directory | [Name]
4,6-DIOXOHEPTANOIC ACID | [CAS]
51568-18-4 | [Synonyms]
SUCCINYLACETONE
4,6-dioxoheptanoicaci
[13C7]-Succinylacetone
4,6-DIOXOHEPTANOIC ACID
Heptanoic acid, 4,6-dioxo-
Succinylacetone-3,4,5,6,7-13C5
4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5 | [Molecular Formula]
C7H10O4 | [MDL Number]
MFCD00002797 | [MOL File]
51568-18-4.mol | [Molecular Weight]
158.15 |
| Chemical Properties | Back Directory | [Melting point ]
66-67 °C(lit.)
| [Boiling point ]
318.7±17.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
powder
| [pka]
4.54±0.17(Predicted) | [color ]
White to Off-White | [CAS DataBase Reference]
51568-18-4 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope
quid urine using a 13C4-SA as internal standard. | [Definition]
ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia. | [Biochem/physiol Actions]
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns. | [storage]
Store at -20°C |
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