| Identification | Back Directory | [Name]
canadine | [CAS]
5096-57-1 | [Synonyms]
C03329
(S)-Canadine
(-)-Canadine
(S)-Tetrahydroberberine
(13As)-5,8,13,13A-tetrahydro-9,10-dimethoxy-6H-benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine
6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, (13aS)- | [EINECS(EC#)]
225-815-0 | [Molecular Formula]
C20H21NO4 | [MDL Number]
MFCD00236139 | [MOL File]
5096-57-1.mol | [Molecular Weight]
339.39 |
| Chemical Properties | Back Directory | [Melting point ]
135° | [alpha ]
D22 -308°; -317° (c = 0.28; 0.4, both in methanol) | [Boiling point ]
475.36°C (rough estimate) | [density ]
1.2270 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform, Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated) | [form ]
Solid | [pka]
6.53±0.20(Predicted) | [color ]
Pale Yellow to Light Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents. | [Uses]
(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or
conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as n
ew antipsychotic agents. | [Definition]
ChEBI: (S)-canadine is the (S)-enantiomer of canadine. It has a role as a plant metabolite. It is functionally related to a (S)-nandinine. It is an enantiomer of a (R)-canadine. | [target]
P450 (e.g. CYP17) |
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| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
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