| Identification | Back Directory | [Name]
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene | [CAS]
50508-60-6 | [Synonyms]
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene
2-Amino-5-ethyl-3-(2-chlorobenzoyl)thiophene
Methanone,(2-aMino-5-ethyl-3-thienyl)(2-chlorophenyl)-
(2-AMino-5-ethylthiophen-3-yl)(2-chlorophenyl)Methanone | [Molecular Formula]
C13H12ClNOS | [MDL Number]
MFCD04107940 | [MOL File]
50508-60-6.mol | [Molecular Weight]
265.758 |
| Chemical Properties | Back Directory | [Boiling point ]
454.8±45.0 °C(Predicted) | [density ]
1.302 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): insol | [form ]
a crystalline solid | [pka]
-1.81±0.10(Predicted) |
| Questions And Answer | Back Directory | [Description]
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene can be used as the raw material for the synthesis of Etizolam, which is an important sedative hypnotic and antidepressant drug. Its derivative, 2-amino-3-(p-chlorobenzoyl) thiophene scaffold has been widely employed as a pharmacophore for the identification of small molecules acting as allosteric modulators at the adenosine A1 receptor.
| [References]
Kai, Yong Mao, et al. "An Improved Synthesis of Etizolam." Journal of Southwest University of Science & Technology (2014).
Romagnoli, R, et al. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study..Longing for the end. Macmillan, 2015:185–204.
|
|
|