| Identification | Back Directory | [Name]
GGTI-2417 | [CAS]
501010-05-5 | [Synonyms]
GGTI-2417
Reaxys ID: 11071519
GGTI 2417
(GGTI2417)
DWKYALWDWAYMTB-FPOVZHCZSA-N
L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester | [Molecular Formula]
C24H33N5O4 | [MDL Number]
MFCD25976817 | [MOL File]
501010-05-5.mol | [Molecular Weight]
455.55 |
| Hazard Information | Back Directory | [Description]
GGTI2417 is a potent and selective Geranylgeranyltransferase I inhibitor that targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. By expressing farnesylated, GGTI-resistant RalA and RalB in Cos7 cells and human pancreatic MiaPaCa2 cancer cells followed by GGTI-2417 treatment, it was demonstrated that farnesylated RalB, but not RalA, confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of GGTI-2417. |
|
|