| Identification | Back Directory | [Name]
ZLN005 | [CAS]
49671-76-3 | [Synonyms]
ZLN005
CS-1004
ZLN005, >=98%
ZLN 005; ZLN-005
2-(4-tert-Butylphenyl)benzimidazole
2-(4-tert-Butylphenyl)-1H-benzimidazole
2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE
2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
2-(4-tert-Butylphenyl)benzimidazole ZLN005
1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-
ZLN005 2-(4-tert-Butylphenyl)benzimidazole | [Molecular Formula]
C17H18N2 | [MDL Number]
MFCD01560221 | [MOL File]
49671-76-3.mol | [Molecular Weight]
250.338 |
| Chemical Properties | Back Directory | [Melting point ]
257-258℃ | [Boiling point ]
415.3±38.0 °C(Predicted) | [density ]
1.102±0.06 g/cm3(Predicted) | [storage temp. ]
?20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
11.52±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. | [Uses]
ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. |
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