| Identification | Back Directory | [Name]
KAEMPFEROL 3-O-GLUCORHAMNOSIDE | [CAS]
482-39-3 | [Synonyms]
AFZELIN
KaeMpferin
Afzeloside
Kaempferol 3-rhamnoside
KAEMPFEROL 3-O-RHAMNOSIDE
Kaempferol 3-O-α-L-Rhamnoside
KAEMPFEROL 3-O-GLUCORHAMNOSIDE
KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE
Afzelin/Kaempferol 3-o-glucorhamnoside
3-(α-L-Rhamnopyranosyloxy)-5,7,4'-trihydroxyflavone
2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl α-L-rhamnopyranoside
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- | [Molecular Formula]
C21H20O10 | [MDL Number]
MFCD00210589 | [MOL File]
482-39-3.mol | [Molecular Weight]
432.38 |
| Chemical Properties | Back Directory | [Melting point ]
172-174 °C (decomp)(Solv: water (7732-18-5)) | [Boiling point ]
765.6±60.0 °C(Predicted) | [density ]
1.70±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in methan | [form ]
powder | [pka]
6.20±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
Afzelin (Synonyms: Kaempferol-3-O-rhamnoside) is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis Induced cardiotoxicity and scopolamine -induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin. | [Uses]
Kaempferol 3-O-α-L-Rhamnoside is found in Cornus macrophylla and has shown to have antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. | [Definition]
ChEBI: A glycosyloxyflavone that is kaempferol attached to a alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. | [References]
[1] SO-YOUNG OH. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia.[J]. Scientific Reports, 2021: 9182. DOI:10.1038/s41598-021-88463-6.
[2] LEI XIA. Afzelin induces immunogenic cell death against lung cancer by targeting NQO2.[J]. BMC Complementary Medicine and Therapies, 2023, 23 1: 381. DOI:10.1186/s12906-023-04221-3.
[3] EVA RACHMI. Identification of afzelin potential targets in inhibiting triple-negative breast cancer cell migration using reverse docking.[J]. Porto biomedical journal, 2020, 5 6: e095. DOI:10.1097/j.pbj.0000000000000095.
[4] SIMPLICE JOEL NDENDOUNG TATSIMO. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum.[J]. BMC Research Notes, 2012, 5: 158. DOI:10.1186/1756-0500-5-158.
[5] YOUNG-KYOON KIM. Isolation of flavonol rhamnosides fromloranthus tanakae and cytotoxic effect of them on human tumor cell lines[J]. Archives of Pharmacal Research, 2004, 27 1: 44-47. DOI:10.1007/BF02980044.
[6] VINIT RAJ. Antiviral activities of 4H-chromen-4-one scaffold-containing flavonoids against SARS–CoV–2 using computational and in vitro approaches[J]. Journal of Molecular Liquids, 2022, 353: Article 118775. DOI:10.1016/j.molliq.2022.118775. |
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