| Identification | Back Directory | [Name]
Alvespimycin | [CAS]
467214-20-6 | [Synonyms]
17-DMAG
CS-2382
DMAG-d6
17-DMAG-d6
Alvespimycin
NSC 707545-d6
AlvespiMycin-d6
Unii-001L2fe0m3
In-house Standard
DMAG Hydrochloride
17-DMAGhydrochloride
AlvespiMycin freebase
AlvespiMycin(17-DMAG)
17-DMAG (Alvespimycin)
NSC 707545 Hydrochloride
(150270-08-9) alvespimycin
17-DMAG;KOS-1022;NSC-707545
17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG
17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin
17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin
17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride
17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin | [Molecular Formula]
C32H48N4O8 | [MDL Number]
MFCD08457919 | [MOL File]
467214-20-6.mol | [Molecular Weight]
616.75 |
| Chemical Properties | Back Directory | [Melting point ]
>270°C (dec.) | [density ]
1.20 | [storage temp. ]
Desiccate at -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Very Dark Purple |
| Hazard Information | Back Directory | [Description]
Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes. | [Chemical Properties]
Solid | [Uses]
17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90. | [Uses]
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. | [Uses]
The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. | [Definition]
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. | [Biological Activity]
Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). |
|
|