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ChemicalBook--->CAS DataBase List--->448895-37-2

448895-37-2

448895-37-2 Structure

448895-37-2 Structure
IdentificationBack Directory
[Name]

NS1643
[CAS]

448895-37-2
[Synonyms]

NS1643, >98%
NS-1643;NS 1643
NS-1643;NS1643;NS 1643
N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-
[Molecular Formula]

C15H10F6N2O3
[MDL Number]

MFCD08705418
[MOL File]

448895-37-2.mol
[Molecular Weight]

380.24
Chemical PropertiesBack Directory
[Boiling point ]

342.3±42.0 °C(Predicted)
[density ]

1.626±0.06 g/cm3(Predicted)
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

DMSO: ≥20mg/mL
[form ]

solid
[pka]

6.84±0.13(Predicted)
[color ]

white to off-white
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-36
[Safety Statements ]

26
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator.
[Biological Activity]

Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro .
[storage]

+4°C
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