| Identification | Back Directory | [Name]
11107B | [CAS]
445493-23-2 | [Synonyms]
11107B
11107AD
PLADIENOLIDE B
SDOUORKJIJYJNW-VGQSKDSZSA-N
(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)- | [Molecular Formula]
C30H48O8 | [MDL Number]
MFCD22572773 | [MOL File]
445493-23-2.mol | [Molecular Weight]
536.7 |
| Chemical Properties | Back Directory | [Boiling point ]
673.8±55.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A clear film | [pka]
13.98±0.70(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Uses]
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. | [Uses]
Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome. | [storage]
Store at -20°C |
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