| Identification | Back Directory | [Name]
Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride | [CAS]
438244-41-8 | [Synonyms]
BBR3438
BBR-3438
Nortopixantrone HCl
Nortopixantrone hydrochloride
Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride | [Molecular Formula]
C20H26Cl2N6O2 | [MOL File]
438244-41-8.mol | [Molecular Weight]
453.365 |
| Hazard Information | Back Directory | [Description]
Nortopixantrone, also known as BBR-3438, is a DNA topoisomerase inhibitor potentially for thetreatment of gastric cancer, ovarian cancer. BR 3438 exhibited a unique profile of preclinical activity with a superior efficacy against prostatic carcinoma models compared to reference compounds (doxorubicin and losoxantrone). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage. |
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