| Identification | Back Directory | [Name]
DPO-1 | [CAS]
43077-30-1 | [Synonyms]
DPO-1
DOP-1 (Diphenyl phosphine oxide-1)
(+)-Neomenthyl diphenylphosphine oxide
inhibit,DPO1,Inhibitor,DPO 1,Potassium Channel,DPO-1,KcsA
(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
Phosphine oxide, [(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-
[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide | [Molecular Formula]
C22H29OP | [MDL Number]
MFCD09038567 | [MOL File]
43077-30-1.mol | [Molecular Weight]
340.44 |
| Hazard Information | Back Directory | [Definition]
ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid. | [Biological Activity]
Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia. | [storage]
Store at +4°C |
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