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ChemicalBook--->CAS DataBase List--->420092-79-1

420092-79-1

420092-79-1 Structure

420092-79-1 Structure
IdentificationBack Directory
[Name]

4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
[CAS]

420092-79-1
[Synonyms]

SW155246
SW155246 >=98% (HPLC)
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-
[Molecular Formula]

C16H11ClN2O5S
[MOL File]

420092-79-1.mol
[Molecular Weight]

378.79
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble10mg/mL, clear
[form ]

powder
[color ]

white to light brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319
[Precautionary statements ]

P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36
[Safety Statements ]

26
Hazard InformationBack Directory
[Description]

SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.
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