| Identification | Back Directory | [Name]
FERUTININ | [CAS]
41743-44-6 | [Synonyms]
FERUTININ
TEFESTROL
Ferutinin >=98% (HPLC)
Ferutinin (high purity)
Ferutinol p-hydroxybenzoate
Jaeschkeanadiol p-hydroxybenzoate | [Molecular Formula]
C22H30O4 | [MDL Number]
MFCD04037015 | [MOL File]
41743-44-6.mol | [Molecular Weight]
358.47 |
| Chemical Properties | Back Directory | [Boiling point ]
489.0±45.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble | [form ]
White to off-white solid | [pka]
8.12±0.15(Predicted) | [color ]
White to off-white | [LogP]
5.720 (est) |
| Hazard Information | Back Directory | [Uses]
Ferutinin acts as an agonist for estrogen receptor (ER) α. It also increases calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes. | [Biological Activity]
Ferutinin can suppress tumor development without causing systemic toxicity in various tumor cells and animal cancer models. It possesses estrogenic properties and a protective role against uterine carcinoma. Ferutinin exhibits anti-cancer action in estrogen-dependent breast cancer cells.''Ferutinin is a strong agonist for estrogen receptor (ER)α and agonist/antagonist for Erβ with IC50 values of 33.1 nM for ERα and 180.5 nM for Erβ. It has been shown to have both ionophoretic and apoptotic properties. It increases calcium permeability in the lipid bilayer and has been shown to improve bone regeneration in a r at study. It caused significant regression in tumor size in a mouse colon cancer model. |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Alfa Chemistry
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+1 (201) 478-8534 |
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www.alfa-chemistry.com |
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MOLEKULA Ltd.
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+44 (0) 1747 831066 |
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www.molekula.co.uk |
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Fluorochem Ltd
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(01457) 868921 (4 lines) |
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www.fluorochem.co.uk |
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Fluorochem Ltd.
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+44 1457 868921 |
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www.fluorochem.net |
| Company Name: |
Abcam
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+1 (877) 774-8286 |
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www.abcam.com |
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