Identification | Back Directory | [Name]
PROSTAGLANDIN D2 | [CAS]
41598-07-6 | [Synonyms]
PGDS PGD2 Prostaglandin D? PROSTAGLANDIN D2 PROSTAGLANDINS D2 PGD2 (Prostaglandin D2) RP23-47P18.11-006, 21kDa 11-dehydroprostaglandinf2-alpha Prostaglandin D2 MaxSpecStandard prostaglandin D2 synthase (brain) prostaglandind2synthetichygroscopic prostaglandin D2 cell culture tested Anti-Ptgds antibody produced in goat Prostaglandin D2 Lipid Maps MS Standard Prostaglandin D - CAS 41598-07-6 - Calbiochem 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID (5Z,13E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid (5z,9α,13e,15s)-9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid [5Z,9ALPHA,13E,15S]9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID 9,15-dihydroxy-11-oxo-,(5z,9-alpha,13e,15s)-prosta-13-dien-1-oicacid Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)- PGD2, (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid 7-[(1R,2R,5S)-5-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid Prostaglandin D2,(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2 (Z)-7-((1R,2R,5S)-5-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-3-oxocyclopentyl)hept-5-enoic acid | [EINECS(EC#)]
636-995-9 | [Molecular Formula]
C20H32O5 | [MDL Number]
MFCD00077857 | [MOL File]
41598-07-6.mol | [Molecular Weight]
352.47 |
Chemical Properties | Back Directory | [Melting point ]
68°C | [alpha ]
+7.5°(D/21℃)(c=1,THF) | [Boiling point ]
406.07°C (rough estimate) | [density ]
1.0601 (rough estimate) | [refractive index ]
1.6120 (estimate) | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly) | [form ]
White solid | [pka]
4.76±0.10(Predicted) | [color ]
White to Light Orange | [BRN ]
2170623 | [Stability:]
Light Sensitive |
Hazard Information | Back Directory | [Description]
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 μM. | [Uses]
Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma. | [Definition]
ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s
ereoisomer). | [Biochem/physiol Actions]
Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase. | [storage]
Store at -20°C, stored under nitrogen |
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