| Identification | Back Directory | [Name]
(-)-Bicucullinemethiodide | [CAS]
40709-69-1 | [Synonyms]
(-)-Bicuculline methiodide
(-)-Bicuculline methiodide
DISCONTINUED. offer B382505
[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-
1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))- | [Molecular Formula]
C21H20INO6 | [MDL Number]
MFCD00078966 | [MOL File]
40709-69-1.mol |
| Chemical Properties | Back Directory | [RTECS ]
JI4904100 | [storage temp. ]
Store at RT | [solubility ]
H2O: soluble10mg/mL, almost clear, greenish-yellow | [form ]
Pale yellow solid. | [color ]
Yellow | [optical activity]
[α]/D -117±7°, c = 1 in chloroform | [BRN ]
5419649 |
| Hazard Information | Back Directory | [Uses]
1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs). | [General Description]
Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP). | [Biological Activity]
Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels. | [Biochem/physiol Actions]
(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor. | [storage]
Room temperature |
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