| Identification | Back Directory | [Name]
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE | [CAS]
40254-90-8 | [Synonyms]
NSC 693868
Brimonidine Impurity 8
3-Aminopyrazolo[3,4-b]quinoxaline
1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine
1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI)
Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem | [Molecular Formula]
C9H7N5 | [MDL Number]
MFCD04038461 | [MOL File]
40254-90-8.mol | [Molecular Weight]
185.19 |
| Chemical Properties | Back Directory | [Melting point ]
292-293℃ (ethanol ) | [Boiling point ]
522.8±45.0 °C(Predicted) | [density ]
1.570±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Red solid | [pka]
7.40±0.50(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Description]
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways. | [Uses]
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents. | [Definition]
ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative. | [Biological Activity]
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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