| Identification | Back Directory | [Name]
BISNORCHOLENALDEHYDE | [CAS]
3986-89-8 | [Synonyms]
BNKY018-PG01
Bisnorcholeldehyde
KETOBISNORALDEHYDE
BISNORCHOLENALDEHYDE
Progesterone Impurity 7
Progesterone Impurity 24
Progesterone EP Impurity I
3-Oxo-pregn-4-ene-20α- carboxaldehyde
Progesterone EP Impurity I (S-isomer)
4-PREGNEN-20BETA-CARBOXALDEHYDE-3-ONE
4-PREGNEN-3-ONE-20-BETA-CARBOXALDEHYDE
3-KETO-4-PREGNENE-20-BETA-CARBOXALDEHYDE
(20S)-3-oxopregn-4-ene-20-carboxaldehyde
Pregn-4-ene-20-carboxaldehyde, 3-oxo-, (20S)-
(S)-2-((8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanal | [Molecular Formula]
C22H32O2 | [MDL Number]
MFCD00056488 | [MOL File]
3986-89-8.mol | [Molecular Weight]
328.49 |
| Chemical Properties | Back Directory | [Melting point ]
159-160 °C | [Boiling point ]
459.4±14.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Androstenedione is the main product after phytosterol fermentation by Mycobacteria. Bisnorcholenaldehyde (BA; 3-Oxopregn-4-ene-20-carboxaldehyde) is one of the by-products produced during fermentation. Bisnorcholenaldehyde is an essential intermediate in the production of progesterone, which is used to treat threatened abortion or habitual abortion disease caused by luteal insufficiency. It is a precursor of androgen, estrogen, glucocorticoid and intermediates of steroid hormone synthesis[1]. In addition, BA is used in magnetic-based graphene composites with steroidal diamine dimer as a potential drug in hyperthermia cancer therapy.
| [Uses]
Bisnorcholenaldehyde is hydrocarbon derivatives and can be used as reference materials for medical impurities. | [Toxics Screening Level]
The initial threshold screening level (ITSL) for progesterone 4 is 0.04 μg/m3 based on an annual averaging time. | [References]
[1] Shi-Dong Xu. “Refining androstenedione and bisnorcholenaldehyde from mother liquor of phytosterol fermentation using macroporous resin column chromatography followed by crystallization.” Journal of Chromatography B 1079 (2018): Pages 9-14.
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| Company Name: |
TOSUN PHARM
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020-61855200 13326451905 |
| Website: |
www.toref.cn/ |
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