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ChemicalBook--->CAS DataBase List--->395-01-7

395-01-7

395-01-7 Structure

395-01-7 Structure
IdentificationBack Directory
[Name]

2,2-DIFLUOROACETOPHENONE
[CAS]

395-01-7
[Synonyms]

A,A-DIFLUOROACETOPHENONE
2,2-DIFLUOROACETOPHENONE
2,2-Difluoroacetophenone97%
2,2-Difluoroacetophenone 97%
2,2-Difluoroacetophenone,95%
2,2-DIFLUORO-1-PHENYLETHANONE
2,2-Difluoro-1-phenylethan-1-one
ALPHA,ALPHA-DIFLUOROACETOPHENONE
Ethanone, 2,2-difluoro-1-phenyl-
Ethanone, 2,2-difluoro-1-phenyl- (9CI)
2,2-Difluoro-1-phenylethan-1-one, 2,2-Difluoro-1-phenyl-1-oxoethane
[Molecular Formula]

C8H6F2O
[MDL Number]

MFCD06246879
[MOL File]

395-01-7.mol
[Molecular Weight]

156.13
Chemical PropertiesBack Directory
[Melting point ]

48-50°C
[Boiling point ]

53-54°C/12mm
[density ]

1.180±0.06 g/mL
[refractive index ]

1.4955
[Fp ]

53-54°C/12mm
[storage temp. ]

under inert gas (nitrogen or Argon) at 2–8 °C
[form ]

liquid
[Water Solubility ]

Immiscible with water.
[CAS DataBase Reference]

395-01-7
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
[HazardClass ]

IRRITANT
[HS Code ]

2914790090
Hazard InformationBack Directory
[Uses]

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
[Synthesis Reference(s)]

Tetrahedron, 52, p. 15, 1996 DOI: 10.1016/0040-4020(95)00884-B
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