| Identification | Back Directory | [Name]
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide | [CAS]
393121-74-9 | [Synonyms]
AA147
(AA 147
AA147 >=98% (HPLC)
ATF6-activator-147
ATF6 agonist compound A147
ATF6-activator-147 (AA147)
N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
Benzenepropanamide, N-(2-hydroxy-5-methylphenyl)- | [Molecular Formula]
C16H17NO2 | [MOL File]
393121-74-9.mol | [Molecular Weight]
255.31 |
| Chemical Properties | Back Directory | [Boiling point ]
460.8±40.0 °C(Predicted) | [density ]
1.190±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL) | [form ]
solid | [pka]
9.68±0.48(Predicted) | [color ]
Beige to pale orange | [Stability:]
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
AA147 (393121-74-9) is a preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2? AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3? It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974. | [storage]
Store at -20°C | [References]
Plate et al. (2016), Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation; Elife 5 e15550
Paxman et al. (2018), Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum, proteins; Elife 7 e37168
Kroeger et al. (2018), The unfolded protein response regulator ATF6 promotes mesodermal differentiation; Sci. Signal. 11 eaan5785
Blackwood et al. (2019), Pharmacological ATF6 activation confers global protection in widespread disease models by reprogramming cellular proteostasis; Nat. Commun. 10 187
Almasy et al. (2021), Small molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections; Proc. Natl. Acad. Sci. USA 118 e2012209118
Rosardo et al. (2021), Metabolically Activated Proteostasis Regulators against Glutamate Toxicity by Activating NRF2; ACS Chem. Biol. 16 2852 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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