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ChemicalBook--->CAS DataBase List--->3854-04-4

3854-04-4

3854-04-4 Structure

3854-04-4 Structure
IdentificationBack Directory
[Name]

trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
[CAS]

3854-04-4
[Synonyms]

CPD3509
Oxotremorine M (iodide)
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
[Molecular Formula]

C11H19IN2O
[MDL Number]

MFCD00055133
[MOL File]

3854-04-4.mol
[Molecular Weight]

322.186
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at -20°C
[solubility ]

DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)
[form ]

Powder
[color ]

Light yellow to yellow
[Water Solubility ]

Soluble to 100 mM in water
Hazard InformationBack Directory
[Description]

Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively). It also increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.
[Uses]

Oxotremorine M is a muscarinic receptor agonist.
[storage]

Desiccate at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide(3854-04-4)1HNMR
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