| Identification | Back Directory | [Name]
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide | [CAS]
383418-30-2 | [Synonyms]
HPA-12
N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide | [Molecular Formula]
C22H37NO3 | [MOL File]
383418-30-2.mol | [Molecular Weight]
363.53 |
| Hazard Information | Back Directory | [Description]
HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM. |
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| Company Name: |
TCI Europe
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| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
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