| Identification | Back Directory | [Name]
TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE | [CAS]
37630-20-9 | [Synonyms]
CID 5380390
Zinc00103738
2,3-dimethoxy-á-nitrostyrene
2,3-DIMETHOXY-SS-NITROSTYRENE
2,3-Dimethoxy-β-nitrostyrene, 98%
trans-2,3-dimethoxy-β-nitrostyrene
2,3-Dimethoxy-^b-nitrostyrene, 98%
(E)-1,2-DiMethoxy-3-(2-nitrovinyl)benzene
1,2-Dimethoxy-3-[(e)-2-nitroethenyl]benzene
1,2-Dimethoxy-3-((E)-2-nitro-vinyl)-benzene
Benzene, 1,2-dimethoxy-3-[(1E)-2-nitroethenyl]-
1,2-Dimethoxy-3-(2-nitrovinyl)benzene, 2-(2,3-Dimethoxyphenyl)nitroethene | [Molecular Formula]
C10H11NO4 | [MDL Number]
MFCD00068082 | [MOL File]
37630-20-9.mol | [Molecular Weight]
209.2 |
| Chemical Properties | Back Directory | [Melting point ]
80-84 °C(lit.)
| [Boiling point ]
328.3±27.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble15mg/mL (clear solution) | [form ]
powder | [color ]
faint yellow to dark yellow |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
CID 5380390 (trans-2,3-Dimethoxy-?-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 5380390 has an IC50 values of 23 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases. |
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| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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