| Identification | Back Directory | [Name]
FENOVERINE | [CAS]
37561-27-6 | [Synonyms]
FENOVERINE
Spasmopriv
Fenoverine D8
3-chloro-3-oxopropanoic acid ethyl ester
10-[(4-Piperonyl-1-piperazinyl)acetyl]-10H-phenothiazine | [EINECS(EC#)]
253-552-1 | [Molecular Formula]
C26H25N3O3S | [MDL Number]
MFCD00865242 | [MOL File]
37561-27-6.mol | [Molecular Weight]
459.56 |
| Chemical Properties | Back Directory | [Melting point ]
141-142° | [Boiling point ]
671.8±55.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.47±0.10(Predicted) | [color ]
Pale Beige to Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Originator]
Spasmopriv,Paillusseau | [Uses]
Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs. | [Definition]
ChEBI: Fenoverine is a member of phenothiazines. | [Manufacturing Process]
To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene
was added a little quantity of bromine and then were added dropwise 136 g
(0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours.
After cooling the mixture was concentrated in vacuo. Product was dissolved at
reflux in ethanol absolute and filtered. At room temperature was crystallized
chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05
mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of
dry toluene was refluxed for 3 hours. Then the solution was cooled and
filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1-
piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P.
141-142°C; yield 67%. | [Therapeutic Function]
Spasmolytic |
|
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LGM Pharma
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