| Identification | Back Directory | [Name]
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate | [CAS]
371924-24-2 | [Synonyms]
Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate | [Molecular Formula]
C23H27N3O2 | [MDL Number]
MFCD02730422 | [MOL File]
371924-24-2.mol | [Molecular Weight]
377.48 |
| Chemical Properties | Back Directory | [Boiling point ]
513.1±50.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM)
Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [pka]
7.21±0.44(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].
MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts. | [storage]
Store at -20°C | [References]
[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.
[2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645. |
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