| Identification | Back Directory | [Name]
PEG7-t-butly ester | [CAS]
361189-64-2 | [Synonyms]
OH-PEG6-TBA
361189-64-2
HO-PEG6-COOtBu
Hydroxy-PEG6-Boc
PEG7-t-butly ester
HO-PEG6-CH2CH2COOtBu
OH-PEG6-CH2CH2COOtBu
HO-PEG4-t-Butyl ester
Hydroxy-PEG6-t-butly ester
Hydroxy-PEG6-t-butyl ester
Hydroxy-dPEG??-t-butyl ester
Hydroxy-PEG6-t-butyl ester 96%
tert-Butyl 1-Hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate
4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C19H38O9 | [MDL Number]
MFCD13185017 | [MOL File]
361189-64-2.mol | [Molecular Weight]
410.5 |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG6-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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