| Identification | Back Directory | [Name]
methysergide | [CAS]
361-37-5 | [Synonyms]
C07199
UML 491
UML-491
Deseril
Desernyl
361-37-5
Methysergid
methysergide
9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8β-carboxamide
Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-
Methylergonovine EP Impurity GQ: What is
Methylergonovine EP Impurity G Q: What is the CAS Number of
Methylergonovine EP Impurity G | [EINECS(EC#)]
206-644-0 | [Molecular Formula]
C21H27N3O2 | [MDL Number]
MFCD00242883 | [MOL File]
361-37-5.mol | [Molecular Weight]
353.46 |
| Chemical Properties | Back Directory | [Melting point ]
194-196° | [alpha ]
D20 -45° (c = 0.5 in pyridine) | [Boiling point ]
486.87°C (rough estimate) | [density ]
1.1377 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) | [form ]
Solid | [pka]
pKa 6.62± 0.02(H2O,t =24,I<0.01)(Approximate) | [color ]
Off-White | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Originator]
Sansert,Sandoz,US,1962 | [Uses]
Methysergide (Methylergonovine EP Impurity G) is a serotonergic receptor antagonist. | [Uses]
Vasoconstrictor (specific in migraine). | [Definition]
ChEBI: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid. | [Manufacturing Process]
As described in US Patent 3,218,324, 0.9 part of potassium are dissolved in 500 parts by volume of liquid ammonia, then oxidized with ferric nitrate to potassium amide, after which 4.85 parts of lysergic acid-1'-hydroxybutylamide-2' are dissolved in the obtained mixture. After 15 minutes there are added to the obtained yellow solution 4.1 parts of methyl iodide in 5 parts by volume of ether, the mixture being allowed to stand for 30 more minutes at -60°C. The liquid ammonia is thereupon evaporated and the dry residue is shaken out between water and chloroform. The mixture of bases which remains after the evaporation of the chloroform is chromatographed on a column of 250 parts of aluminum oxide, the desired 1-methyl-lysergic acid-1'- hydroxy-butylamide-2' being washed into the filtrate with chloroform and chloroform-0.2% ethanol. The 1-methyl-lysergic acid-1'hydroxy-butylamide-2' crystallizes from chloroform in the form of plates which melt at 194° to 196°C. Reaction with maleic acid gives the dimaleate, melting at 187° to 188°C. | [Therapeutic Function]
Migraine therapy | [Clinical Use]
Methysergide (Sansert), which is structurally identical to methylergonovine except for the addition of a methyl group to the indole nitrogen, has far less of the uterine
stimulatory properties of the other agents and, instead, is used exclusively for treatment of migraine headache as a serotonin antagonist at 5-HT1/5-HT2 receptors.Methysergide is a potent peripheral inhibitor of 5-HT receptors in the blood vessel, which inhibits vessel-wall permeability. Methysergide also inhibits the release of
histamine from mast cells and stabilizes platelets against the release of 5-HT, which may be responsible for the onset of the migraine attack. In contrast to its
peripheral effects, methysergide appears to be a central 5-HT1 agonist, resulting in alleviation of the central hyperalgesia effect that occurs in patients with migraine. |
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