| Identification | Back Directory | [Name]
AMIPROFOS METHYL | [CAS]
36001-88-4 | [Synonyms]
ntn80
ntn6867
bayntn80
NTN-2925
Tokunol-M
bayntn6867
amiprophosmethyl
AMIPROFOS METHYL
Amiprofosmethylbiochemika
O-METHYL O-(2-NITRO-P-TOLYL) N-ISOPROPYL-PHOSPHORAMIDOTHIONATE
O-methyl O-(4-methyl-2-nitrophenyl) isopropylthiophosphorami...
O-methyl O-(4-methyl-2-nitrophenyl) isopropylthiophosphoramidate
n-isopropyl-phosphoramidothioicacio-methylo-(2-nitro-p-tolyl)ester
O-methyl-O-(2-nitro-4-methylpehnyl)-N-isopropylphosphoramidothioate
o-methylo-(4-methyl-2-nitrophenyl)(1-methylethyl)phosphoramidothioate
N-Isopropylphosphoramidothioic acid O-methyl O-(4-methyl-2-nitrophenyl)
Amiprofos methyl,O-Methyl O-(2-nitro-p-tolyl) N-isopropylphosphoramidothionate
Phosphoramidothioic acid, N-(1-methylethyl)-, O-methyl O-(4-methyl-2-nitrophenyl) ester | [EINECS(EC#)]
252-829-4 | [Molecular Formula]
C11H17N2O4PS | [MDL Number]
MFCD00467096 | [MOL File]
36001-88-4.mol | [Molecular Weight]
304.3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3
| [RTECS ]
TB5100000
| [Toxicity]
LD50 orl-rat: 309 mg/kg 85AREA 2,212,77 |
| Hazard Information | Back Directory | [Description]
Amiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM. | [Uses]
Amiprofos-methyl is useful in herbicide compositions. | [Biochem/physiol Actions]
Herbicide that prevents microtubule polymerization in plant cells, but not animal cells. Crop plants resistant to amiprofos-methyl and several other herbicides have been developed by insertion of a xenobiotic-detoxifying human gene CYP2B6. | [Safety Profile]
A poison by ingestion. Lowtoxicity by skin contact. When heated to decomposition itemits toxic vapors of NOx, SOx, and POx. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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