| Identification | Back Directory | [Name]
UBCS039 | [CAS]
358721-70-7 | [Synonyms]
UBCS039
Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)- | [Molecular Formula]
C16H13N3 | [MDL Number]
MFCD00206184 | [MOL File]
358721-70-7.mol | [Molecular Weight]
247.29 |
| Chemical Properties | Back Directory | [Boiling point ]
453.9±45.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 125 mg/mL (505.48 mM) | [form ]
Solid | [pka]
4.66±0.12(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines. | [in vitro]
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
|
Cell Line:
|
Human H1299 cells.
|
|
Concentration:
|
75 μM.
|
|
Incubation Time:
|
48 and 72 hours.
|
|
Result:
|
Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.
|
Cell Proliferation Assay
|
Cell Line:
|
Human H1299 cells.
|
|
Concentration:
|
100 μM.
|
|
Incubation Time:
|
48 and 72 hours.
|
|
Result:
|
Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
|
| [target]
| Target | Value | SIRT6
(Cell-free assay) | 38 μM(EC50) |
|
|
| Company Name: |
Henan Alpha Chemical Co., Ltd.
|
| Tel: |
0371-0371-55055611 18137792234 |
| Website: |
www.approvedhomemanagement.com/showsupplierproductslist31206/0.htm |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
|