| Identification | Back Directory | [Name]
N-nervonoyl-D-erythro-sphinganine | [CAS]
352518-80-0 | [Synonyms]
C24:1-dihydro-Ceramide
N-nervonoyl-D-erythro-sphinganine
C24:1 Dihydroceramide (d18:0/24:1(15Z))
N-NERVONOYL-D-ERYTHRO-SPHINGANINE;C24:1 DIHYDROCERAMIDE (D18:0/24:1(15Z)) | [Molecular Formula]
C42H83NO3 | [MDL Number]
MFCD02259305 | [MOL File]
352518-80-0.mol | [Molecular Weight]
650.11 |
| Chemical Properties | Back Directory | [Boiling point ]
750.0±50.0 °C(Predicted) | [density ]
0.906±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
14.30±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
C24:1 Dihydroceramide has been used as a standard in quadrupole time-of-flight (Q-TOF) mass spectrometry for the measurement of sphingolipid metabolites in adipose tissue. It has also been used a standard in diacylglycerol kinase (DGK) assay to quantify dihydroceramides in CLN9-deficient cells. | [Definition]
ChEBI: N-[(15Z)-tetracosenoyl]sphinganine is a dihydroceramide in which the ceramide N-acyl group is specified as (15Z)-tetracosenoyl (nervonoyl). It has a role as a mouse metabolite. It is a C24:1-sphinganine and a Cer(d42:1). It is functionally related to a (15Z)-tetracosenoic acid. | [Biological Activity]
C24:1 Dihydroceramide is a synthetic dihydroceramide. Dihydroceramides are reduced to ceramides by the enzyme dihydroceramide desaturase. Elevated levels of serum 24:1 DHC has been observed in patients with history of hepatocellular carcinoma (HCC) pre-orthopic liver transplantation (OLT)compared to patients with no prior HCC. Therefore24:1 DHC can be used as a HCC biomarker in post-OLT patients. |
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