| Identification | Back Directory | [Name]
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem | [CAS]
335166-00-2 | [Synonyms]
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem | [Molecular Formula]
C19H21Br2ClFN3 | [MDL Number]
MFCD20926332 | [MOL File]
335166-00-2.mol | [Molecular Weight]
505.65 |
| Hazard Information | Back Directory | [Uses]
iMAC2 is a mitochondrial apoptosis-induced channel (MAC) inhibitor. | [General Description]
A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 μM). | [storage]
Desiccate at RT |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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