| Identification | Back Directory | [Name]
N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide | [CAS]
329059-55-4 | [Synonyms]
BRD7116
BRD7716
BRD-7116;BRD 7116
BRD7116 >=98% (HPLC)
BRD7116;BRD-7116;BRD 7116
N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)
2,2,3,3-Tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide | [Molecular Formula]
C28H36N2O4S | [MDL Number]
MFCD02168947 | [MOL File]
329059-55-4.mol | [Molecular Weight]
496.66 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
BRD 7116 (329059-55-4) inhibits leukemia stem cell (LSC) activity (EC50 = 200 nM). Displays a >100-fold selectivity for LSCs over normal hematopoietic stem cells.1 | [Uses]
BRD 7116 inhibits LSCe (leukemia stem cell) and HSPCs (Hematopoietic stem cells ), by displaying cell-non-autonomous anti-leukemia activity. | [Definition]
ChEBI: 2,2,3,3-tetramethyl-N-[4-[4-[[oxo-(2,2,3,3-tetramethylcyclopropyl)methyl]amino]phenyl]sulfonylphenyl]-1-cyclopropanecarboxamide is an anilide. | [storage]
+4°C | [References]
1) Hartwell et al. (2013), Niche-based screening identifies small-molecule inhibitors of leukemia stem cells; Nat. Chem. Biol., 9 840 |
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