| Identification | Back Directory | [Name]
COCHLIOQUINONE B | [CAS]
32450-26-3 | [Synonyms]
COCHLIOQUINONE B
20-De(acetyloxy)-11-deoxy-20-oxocochlioquinone A
Pyrano[3,2-a]xanthene-8,11-dione, 9-[(1S,3S)-1,3-dimethyl-2-oxopentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethyl-, (3R,4aR,6aR,12aR,12bR)- | [Molecular Formula]
C28H40O6 | [MDL Number]
MFCD31557718 | [MOL File]
32450-26-3.mol | [Molecular Weight]
472.61 |
| Chemical Properties | Back Directory | [Boiling point ]
579.4±50.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [pka]
14.54±0.29(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cochlioquinone B is an NADH ubiquinonereductase inhibitor and a phytotoxic agent. A metabolite of Cochliobolus miyabeanus. | [Uses]
Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have recently been shown to be antagonists of the human chemokine receptor, CCR5, in HIV-1. |
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