| Identification | Back Directory | [Name]
6-[(1-NaphthalenylMethyl)thio]-9H-purine | [CAS]
313984-77-9 | [Synonyms]
PU 02
PU-02; PU02
6-[(1-NaphthalenylMethyl)thio]-9H-purine
6-((Naphthalen-1-ylmethyl)thio)-7H-purine
9H-Purine, 6-[(1-naphthalenylmethyl)thio]-
6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine | [Molecular Formula]
C16H12N4S | [MDL Number]
MFCD23381174 | [MOL File]
313984-77-9.mol | [Molecular Weight]
292.36 |
| Hazard Information | Back Directory | [Description]
PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis. |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
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13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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