| Identification | Back Directory | [Name]
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole | [CAS]
308357-81-5 | [Synonyms]
4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-8-(phenylsulfonyl)-1,5-undecadi
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole | [Molecular Formula]
C36H61NO4S2Si2 | [MOL File]
308357-81-5.mol | [Molecular Weight]
692.175 |
| Chemical Properties | Back Directory | [Appearance]
Colourless Oil | [Boiling point ]
691.6±55.0 °C(Predicted) | [density ]
1.027±0.06 g/cm3(Predicted) | [solubility ]
Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene | [form ]
Oil | [pka]
2.72±0.10(Predicted) | [color ]
Colourless | [CAS DataBase Reference]
308357-81-5 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Oil | [Uses]
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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Energy Chemical
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http://www.energy-chemical.com |
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Carbosynth
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www.carbosynth.com |
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Medical Isotopes
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www.medicalisotopes.com |
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