| Identification | Back Directory | [Name]
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate | [CAS]
307519-88-6 | [Synonyms]
NMDI14
NMDI14 >=97% (HPLC)
inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester | [Molecular Formula]
C21H25N3O4S | [MDL Number]
MFCD02073967 | [MOL File]
307519-88-6.mol | [Molecular Weight]
415.51 |
| Chemical Properties | Back Directory | [Boiling point ]
658.8±55.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO : ≥ 25 mg/mL (60.17 mM) | [form ]
powder | [pka]
13.42±0.40(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
- to study its effects on differentiating cardiomyocytes
- to study its effects on zebrafish pdzk1 gene-knockout embryos
- to analyze its effects on the apoptosis of colorectal cancer cells
| [Biochem/physiol Actions]
NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Twochem Co.Ltd.
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021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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