| Identification | Back Directory | [Name]
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate | [CAS]
300803-69-4 | [Synonyms]
STOML3 inhibitor OB-1
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate
3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester | [Molecular Formula]
C21H17N3O6 | [MDL Number]
MFCD01462999 | [MOL File]
300803-69-4.mol | [Molecular Weight]
407.38 |
| Hazard Information | Back Directory | [Biological Activity]
OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3)which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activityOB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain. | [storage]
Store at RT |
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