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ChemicalBook--->CAS DataBase List--->29876-14-0

29876-14-0

29876-14-0 Structure

29876-14-0 Structure
IdentificationBack Directory
[Name]

Nicotredole
[CAS]

29876-14-0
[Synonyms]

tryptamide
Nicotredole
N-[2-(3-indolyl)ethyl]nicotinamide
N-(2-(1H-Indol-3-yl)ethyl)nicotinaMide
N-[2-(1H-indol-3-yl)ethyl]pyridine-3-carboxamide
3-Pyridinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]-
[Molecular Formula]

C16H15N3O
[MDL Number]

MFCD00841846
[MOL File]

29876-14-0.mol
[Molecular Weight]

265.31
Chemical PropertiesBack Directory
[Boiling point ]

408.53°C (rough estimate)
[density ]

1.0944 (rough estimate)
[refractive index ]

1.6500 (estimate)
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

DMSO: 25 mg/mL (94.23 mM)
[form ]

Solid
[color ]

Light brown to brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
Hazard InformationBack Directory
[Biological Activity]

Nicotredole (Tryptamide) is an orally active anti-inflammatory analgesic. It showed significant anti-inflammatory effects comparable to Phenylbutazone.
[in vitro]

Nicotredole inhibits prostaglandin synthetase activity in vitro.

[in vivo]

Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema.
It reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice.
Nicotredole (ip) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively.
Nicotredole (po) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively.
Nicotredole (25 mg/kg; po or ip) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg?h/cm 3 ).

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