| Identification | Back Directory | [Name]
BML-286 | [CAS]
294891-81-9 | [Synonyms]
BML-286
2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid
2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid
Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]- | [Molecular Formula]
C22H18N2O4 | [MOL File]
294891-81-9.mol | [Molecular Weight]
374.39 |
| Hazard Information | Back Directory | [Uses]
BML-286 is a small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.
| [Definition]
ChEBI: 2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid is a member of benzamides. | [General Description]
A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 μM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 μM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 μM; IC50 = 12.5 μM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 μM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo. |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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