| Identification | Back Directory | [Name]
Y320 | [CAS]
288250-47-5 | [Synonyms]
Y320
288250-47-5
Y-320, >=98%
1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C27H29ClN6O2 | [MDL Number]
MFCD28099803 | [MOL File]
288250-47-5.mol | [Molecular Weight]
505.011 |
| Chemical Properties | Back Directory | [Boiling point ]
631.2±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH | [form ]
solid | [pka]
11.82±0.70(Predicted) | [color ]
Off-white to pink |
| Questions And Answer | Back Directory | [Description]
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. | [In vitro]
Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. | [In vivo]
Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. |
| Hazard Information | Back Directory | [Uses]
1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice. | [Biological Activity]
y-320 is a new phenylpyrazoleanilide immunomodulator [1].immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.y-320 is a new phenylpyrazoleanilide immunomodulator. y-320 inhibited il-17 production by cd4 t cells induced by il-15 with ic50 values of 20-60 nm [1].in type ii collagen-induced arthritis (cia) mice, oral administration of y-320 (0.3-3 mg/kg) reduced il-17 mrna expression and significantly inhibited the development of joint destruction and arthritis. the combination of y-320 with anti-murine tumor necrosis factor-α (tnf-α) monoclonal antibody exhibited a synergistic effect. in cynomolgus monkeys, y-320 (0.3-1 mg/kg) relieved cia. these results suggested that y-320 could be a useful candidate for therapy of rheumatoid arthritis (ra) [1]. | [References]
[1]. ushio h, ishibuchi s, oshita k, et al. a new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. pharmaceuticals (basel), 2013, 7(1): 1-17. |
|
|