| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2775311-17-4 | [Synonyms]
| [Molecular Formula]
C22H23F4N5O | [Molecular Weight]
449.44 |
| Chemical Properties | Back Directory | [Boiling point ]
518.5±50.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.94±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1]. | [References]
[1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596. |
|
|