| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-[4-methoxy-5-(1-pyrrolidinylcarbonyl)-3-thienyl]-1H-1,2,3-triazol-1-yl]- | [CAS]
2766385-56-0 | [Synonyms]
2,6-Piperidinedione, 3-[4-[4-methoxy-5-(1-pyrrolidinylcarbonyl)-3-thienyl]-1H-1,2,3-triazol-1-yl]- | [Molecular Formula]
C17H19N5O4S | [MOL File]
2766385-56-0.mol | [Molecular Weight]
389.43 |
| Chemical Properties | Back Directory | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100mg/mL(256.79 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
10.40±0.40(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Description]
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1]. TMX-4116 (compound 16; 1 μM; 4 h) shows a high degradation preference for CK1α in MOLT4 cells[1].TMX-4116 (250 nM, 4 h) induces primary target degradation of CK1α, while no downregulation of PDE6D, IKZF1, and IKZF3 in MOLT4 cells[1]. | [References]
[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. |
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