| Chemical Properties | Back Directory | [solubility ]
DMF:2.0(Max Conc. mg/mL);4.18(Max Conc. mM)
DMSO:3.0(Max Conc. mg/mL);6.27(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.18(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DX3-213B is a potent Oxidative Phosphorylation Inhibitor (MIA PaCa-2 GI50 = 11 nM) for the Treatment of Pancreatic Cancer. DX3-213B disrupts adenosine triphosphate (ATP) generation, inhibits complex I function, and results in the growth inhibition of pancreatic cancer cells in the low nanomolar range. Importantly, the oral administration of DX3-213B resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity. |
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