| Identification | Back Directory | [Name]
11BETA-PROSTAGLANDIN E1 | [CAS]
27415-26-5 | [Synonyms]
15-F2t-IsoP
8-epi-PGF2α
8-Iso-PGF2α
8-ISOPROSTANE
IPF2ALPHA-III
15-F2t-IsoP-d9
8-epi-PGF2α-d9
8-Iso-PGF2α-d9
8-EPI PGF2ALPHA
15(S)-8-Iso-PGF2α
15-F2t-Isoprostane
15-F2t-Isoprostane-d9
8-Isoprostaglandin F2a
8-epi-Prostaglandin F2α
8-iso Prostaglandin F2α
8-Isoprostaglandin F2α-d9
8-iso-Prostaglandin F2α-d9
8-ISO PROSTAGLANDIN F2ALPHA
8-EPI PROSTAGLANDIN F2ALPHA
Isoprostaglandin F2α type-III
8-ISOPROSTAGLANDIN F2ALPHA, >99%
Isoprostaglandin F2α type-III-d9
8-epi-Prostaglandin F2α
8-iso Prostaglandin F2α MaxSpec Standard
8-iso Prostaglandin F2α MaxSpec? Standard
(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid
9ALPHA, 11ALPHA15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC ACID
(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid-d9
7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-Heptenoic Acid-d9
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9α,11α,13E,15S)-
(Z)-7-[(1S,2S,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenty | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00084822 | [MOL File]
27415-26-5.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [Boiling point ]
531.0±50.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml | [form ]
A crystalline solid | [pka]
4.76±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3 It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.1,2 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.4 Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.3 | [Description]
8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3 It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.1,2 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.4 Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.3
8-iso Prostaglandin F2α MaxSpec® standard is a quantitative grade standard of 8-iso Prostaglandin F2α (Item No. 16350) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F2α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. | [Uses]
(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.
| [Uses]
A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress. | [Definition]
ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
amyjetsci
|
| Tel: |
027-59626688 18771149750 |
| Website: |
https://www.amyjet.com/ |
|