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ChemicalBook--->CAS DataBase List--->2739805-64-0

2739805-64-0

2739805-64-0 Structure

2739805-64-0 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2739805-64-0
[Synonyms]

NT1-O14B
[Molecular Formula]

C40H68N2O4S4
[MOL File]

2739805-64-0.mol
[Molecular Weight]

769.23
Chemical PropertiesBack Directory
[Boiling point ]

812.9±65.0 °C(Predicted)
[density ]

1.098±0.06 g/cm3(Predicted)
[solubility ]

Ethanol: Soluble
[form ]

Viscous Liquid
[pka]

17.27±0.30(Predicted)
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Description]

NT1-O14B is a tryptamine-containing ionizable cationic lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and the cationic lipidoid 306-O12B-3 encapsulating antisense oligonucleotides (ASOs) against tau decreases tau brain levels in mice.
[References]

1. Ma, F., Yang, L., Sun, Z., et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection Sci. Adv. 6(30),eabb4429(2020).
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