| Identification | Back Directory | [Name]
1-(2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-2H-PYRIDIN-1-YL]-ETHYL)-3-ISOPROPYL-6-METHANESULFONYL-3,4-DIHYDRO-1H-BENZO[1,2,6]THIADIAZINE 2,2-DIOXIDE | [CAS]
271780-64-4 | [Synonyms]
LY-393558
1-(2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-2H-PYRIDIN-1-YL]-ETHYL)-3-ISOPROPYL-6-METHANESULFONYL-3,4-DIHYDRO-1H-BENZO[1,2,6]THIADIAZINE 2,2-DIOXIDE
1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
1H-2,1,3-BENZOTHIADIAZINE, 1-[2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]ETHYL]-3,4-DIHYDRO-3-(1-METHYLETHYL)-6-(METHYLSULFONYL)-, 2,2-DIOXIDE | [Molecular Formula]
C26H31FN4O4S2 | [MDL Number]
MFCD10565930 | [MOL File]
271780-64-4.mol | [Molecular Weight]
546.68 |
| Chemical Properties | Back Directory | [Boiling point ]
785.7±60.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder | [pka]
16.46±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
LY 393558 acts as a 5HT1B/D receptor antagonist which has been shown to limit serotonin reuptake on extracellular levels. Potential use in the treatment of IBS. | [Biological Activity]
Dual 5-HT 1B/1D receptor antagonist (pK B values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC 50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine in vivo . Also acts as an antagonist at 5-HT 2A and 5-HT 2B receptors (pK i values are 7.29 and 7.35 respectively). | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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