| Hazard Information | Back Directory | [Uses]
PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein (HY-169967); black: linker (HY-169966); Blue: E3 ligase ligand (HY-125845))[1]. | [in vivo]
PROTAC AR Degrader-5 (compound A46) (100, 200, 400, 800 μg + 12 μg TP; Skin application; daily for 21 days) inhibits sebaceous plaque in golden hamster[1].
PROTAC AR Degrader-5 (5, 10, 30 mg/ml +DHT 30 mpk; 150 μL; Skin application; 2 times a day for 17 days) induces hair regeneration in C57BL/6N mice[1]. | Animal Model: | 7-8 weeks, 90-110g, Female Golden hamster[1] | | Dosage: | 100, 200, 400, 800 μg + 12 μg TP | | Administration: | Skin application; daily for 21 days | | Result: | Inhibited sebaceous plaque with the inhibition rate of 19.24%, 35.20%, 49.54%, 51.61% at 100, 200, 400, 800 μg, respectively. |
| [References]
[1] YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1. |
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