| Identification | Back Directory | [Name]
Ethanone, 2-[4-(5-fluoro-2-pyridinyl)-1-piperazinyl]-1-(2-methylimidazo[1,2-a]pyridin-3-yl)- | [CAS]
2650944-83-3 | [Synonyms]
FATP1-IN-2
Ethanone, 2-[4-(5-fluoro-2-pyridinyl)-1-piperazinyl]-1-(2-methylimidazo[1,2-a]pyridin-3-yl)- | [Molecular Formula]
C19H20FN5O | [MOL File]
2650944-83-3.mol | [Molecular Weight]
353.39 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
6.00±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
FATP1-IN-2, as an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1].
FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1].FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1]. | [References]
[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565. |
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