| Identification | Back Directory | [Name]
1-Pyrrolidinesulfonamide, N-[2-cyano-3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)oxy]-4-fluorophenyl]-3-fluoro-, (3R)- | [CAS]
2649372-20-1 | [Synonyms]
B-Raf IN 2
BRAF inhibitor Compound Ia
(R)-N-(2-cyano-4-fluoro-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)oxy)phenyl)-3-fluoropyrrolidine-1-sulfonamide
1-Pyrrolidinesulfonamide, N-[2-cyano-3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)oxy]-4-fluorophenyl]-3-fluoro-, (3R)- | [Molecular Formula]
C20H17F2N5O4S | [MOL File]
2649372-20-1.mol | [Molecular Weight]
461.44 |
| Chemical Properties | Back Directory | [Boiling point ]
621.4±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
5.79±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer[1].
B-Raf IN 2 shows considerably less paradoxial activation of the MAPK signaling pathway while retaining high potency[1]. | [References]
[1]. Dolente C, et, al. New methylquinazolinone derivatives. WO2021116055A1. |
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