| Identification | Back Directory | [Name]
2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- | [CAS]
2648453-53-4 | [Synonyms]
JH-XVI-178
2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- | [Molecular Formula]
C22H22ClN7O | [MOL File]
2648453-53-4.mol | [Molecular Weight]
435.91 |
| Chemical Properties | Back Directory | [Boiling point ]
782.1±60.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
9.84±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties. | [References]
[1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693. |
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